Depends on the year.
On my 83 I had, I ran a splitter pipe and dual glasspacks, gave it a nice rumble at idle and stayed pretty throaty untill you really rapped it, then it sounded like a ups truck on steroids.
My 96, actually all EFI 300 6's have a split exhaust manifold, instead of the single like the old ones, so its possible to run true duals on them. I havent done anything with my 96 yet, but probley some glasspacks is what im gonna run.
go here.....www.fordsix.com......they got all kinds of info on Straight 6's.
later,
Dustin