Yes and No. The F-100 has a wider stance so the brake lines are a little longer. The brake hoses are also alittle longer. Both the lines and hoses are the same size at the connections and would swap if the length is not a proplem. I completly re did my brake lines and hoses last winter on my 70 f-100. I put in a 4 inch lift so I bought early bronco extended brake hoses from JBG. and universal brake lines from auto zone. Hope that helps RKDxpress.